Rh(III)-Catalyzed C–H Activation of Benzamides and Chemodivergent Annulation with Benzoxazinanones:

Substrate Controlled Selectivity

Decarboxylative annulation of propargyl carbamates with benzamides has been realized via rhodium-catalyzed C–H bond activation under mild conditions, delivering two distinct classes of heterocycles in high efficiency and selectivity under substrate control. This protocol provides a direct synthetic method for the preparation of functionalized 1,8-naphthyridines and isoindolinones.

(Org. Lett. 2023, 10.1021/acs.orglett.3c02371)

Congratulations to Danqing Ji.