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Prof. Li
School of chemistry and Chemical Engineering, Shaanxi Normal University
Professional Information
Position: Professor of Organic Chemistry
Email: lixw@snnu.edu.cn;
TEL: 029-8531-8783
2001 – 2005 Ph. D (2005) and M. S. (2005) in inorganic chemistry, Yale University Advisor: Robert H. Crabtree
1999 – 2001 Graduate study, State University of New York at Albany (school transferring to Yale)
1991 – 1996 B. S. (1996) in chemistry, Fudan University, China
2018---present Professor of Organic Chemistry, Shaanxi Normal University, School of chemistry and Chemical Engineering
2010---2018 Professor of Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
2008---2009 Assistant Professor of Catalysis, The Scripps Research Institute, Scripps Florida
2006---2008 Assistant Professor, Nanyang Technological University, Singapore
2005---2006 Postdoctoral Scholar, California Institute of Technology, advisor: Prof. John E. Bercaw
2018 Highly Cited Researchers in the 2006-2016 Period (Web of Science)
2018 The Ten-Thousand Project (Leading Talent in Science & Technology)
2017 One of the Highly Prolific Authors Selected by Org. Lett. (with most published articles in the past 5 years)
2015 Recipient of National Distinguished Young Researcher Fund
2012, 2015 Research Awards, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
2005 Richard Wolfgang Prize for Best Ph. D. Thesis, Graduate School of Arts and Sciences, Yale University
Associate Editor of Chinese Journal of Catalysis (2014-2019)
Fellow, RSC (Since 2015）
Adjunct Professor, Henan Normal University
(1) Homogeneous Catalysis
Design of metal catalysts for new organic transformations
Transition metal (rhodium and palladium) catalyzed oxidative C-C, C-O, and C-N coupling based on C-H activation
Synthesis of heterocycles via metal catalyzed reaction methodologies
Selective activation and oxidation of C-H bonds, oxidation of methane to methanol
C-C coupling reactions involving alkynes.
Alkyne and alkene hydroamination
Anaerobic oxidation (dehydrogenation) of alcohols and other hydrogen-transfer reactions involving alcohols and amines.
(2) Synthetic Organometallic Chemistry
Synthesis of metal complexes of Rh, Ir, Ru, Pt, and Pd, particularly with N-heterocyclic carbenes (NHC)
Synthesis of complexes with abnormal binding modes of N-Heterocyclic Carbenes
Synthesis and reactivity of N-heterocyclic carbenes
Synthesis of late transition metal complexes featuring multi-dentate ligands with flexible binding modes.
Structural and reactivity studies
(3) Mechanistic Organometallic Chemistry
Inter- and intramolecular activation of C-H and C-C bonds.
Metal-ligand cooperation/interactions in organometallic chemistry
Hydrogen transfer reactions (hydrogenation, dehydrogenation, and transfer hydrogenation)
Research methods: dynamic NMR spectroscopy, intermediate isolation, X-ray crystallography, isotope labeling, and reaction kinetics.
2010---Present Supervised 20 graduate students and three postdocs in research
2006---2008 Nanyang Technological University, Singapore
2002-2005 Yale College Math and Science Tutor
1. Song, G., Wang, F., & Li, X. (2012). C-C, C-O and C-N bond formation via rhodium (III)-catalyzed oxidative C-H activation. Chemical Society Reviews, 41(9), 3651-3678.
2. Wang, F., Yu, S., & Li, X. (2016). Transition metal-catalysed couplings between arenes and strained or reactive rings: combination of C-H activation and ring scission. Chemical Society Reviews, 45(23), 6462-6477.
3. Song, G., & Li, X. (2015). Substrate activation strategies in rhodium (III)-catalyzed selective functionalization of arenes. Accounts of chemical research, 48(4), 1007-1020.
4. Li, X., Incarvito, C. D., & Crabtree, R. H. (2003). A rare η2-butadienyl complex from an alkyne double insertion with double vinylidene rearrangement. Journal of the American Chemical Society, 125(13), 3698-3699.
5. Xie, F., Qi, Z., Yu, S., & Li, X. (2014). Rh(III)-and Ir(III)-Catalyzed C-H Alkynylation of Arenes under Chelation Assistance. Journal of the American Chemical Society, 136(12), 4780-4787.
6. Yu, S., Liu, S., Lan, Y., Wan, B., & Li, X. (2015). Rhodium-catalyzed C-H activation of phenacyl ammonium salts assisted by an oxidizing C-N bond: a combination of experimental and theoretical studies. Journal of the American Chemical Society, 137(4), 1623-1631.
7. Wu, J. Q., Zhang, S. S., Gao, H., Qi, Z., Zhou, C. J., Ji, W. W., Li，X. & Wang, H. (2017). Experimental and theoretical studies on rhodium-catalyzed coupling of benzamides with 2, 2-difluorovinyl tosylate: diverse synthesis of fluorinated heterocycles. Journal of the American Chemical Society, 139(9), 3537-3545.
8. Xiao, J., & Li, X. (2011). Gold α‐Oxo Carbenoids in Catalysis: Catalytic Oxygen‐Atom Transfer to Alkynes. Angewandte Chemie International Edition, 50(32), 7226-7236.
9. Song, G., Chen, D., Su, Y., Han, K., Pan, C. L., Jia, A., & Li, X. (2011). Isolation of azomethine ylides and their complexes: iridium(III)-mediated cyclization of nitrone substrates containing alkynes. Angewandte Chemie International Edition, 50(34), 7791-7796.
10. Zhen, W., Wang, F., Zhao, M., Du, Z., & Li, X. (2012). Rhodium(III)-Catalyzed Oxidative C- H Functionalization of Azomethine Ylides. Angewandte Chemie International Edition, 51(47), 11819-11823.
11. Li, X., Yu, S., Wang, F., Wan, B., & Yu, X. (2013). Rhodium(III)-Catalyzed C-C Coupling between Arenes and Aziridines by C-H Activation. Angewandte Chemie International Edition, 52(9), 2577-2580.
12. Xie, F., Qi, Z., & Li, X. (2013). Rhodium(III)‐Catalyzed Azidation and Nitration of Arenes by C-H Activation. Angewandte Chemie International Edition, 52(45), 11862-11866.
13. Qi, Z., & Li, X. (2013). Rhodium(III)-Catalyzed Coupling of Arenes with 7‐Oxa/Azabenzonorbornadienes by C-H Activation. Angewandte Chemie International Edition, 52(34), 8995-9000.
14. Zhang, X., Qi, Z., & Li, X. (2014). Rhodium(III)‐Catalyzed C-C and C-O Coupling of Quinoline N-Oxides with Alkynes: Combination of C-H Activation with O-Atom Transfer. Angewandte Chemie International Edition, 53(40), 10794-10798.
15. Wang, H., Tang, G., & Li, X. (2015). Rhodium (III)-Catalyzed Amidation of Unactivated C (sp3)-H Bonds. Angewandte Chemie International Edition, 54(44), 13049-13052.
16. Xie, F., Zhang, Z., Yu, X., Tang, G., & Li, X. (2015). Diaryliodoniums by Rhodium(III)‐Catalyzed C-H Activation: Mild Synthesis and Diversified Functionalizations. Angewandte Chemie International Edition, 54(25), 7405-7409.
17. Yu, S., Tang, G., Li, Y., Zhou, X., Lan, Y., & Li, X. (2016). Anthranil: An Aminating Reagent Leading to Bifunctionality for Both C(sp3)-H and C(sp2)-H under Rhodium(III) Catalysis. Angewandte Chemie International Edition, 55(30), 8696-8700.
18. Li, Y., Qi, Z., Wang, H., Yang, X., & Li, X. (2016). Ruthenium(II)-Catalyzed C-H Activation of Imidamides and Divergent Couplings with Diazo Compounds: Substrate-Controlled Synthesis of Indoles and 3H-Indoles. Angewandte Chemie International Edition, 55(39), 11877.
19. Xie, F., Yu, S., Qi, Z., & Li, X. (2016). Nitrone Directing Groups in Rhodium(III)-Catalyzed CH Activation of Arenes: 1, 3-Dipoles versus Traceless Directing Groups. Angewandte Chemie International Edition, 55(49), 15351.
20. Zhou, X., Pan, Y., & Li, X. (2017). Catalyst-Controlled Regiodivergent Alkyne Insertion in the Context of C-H Activation and Diels-Alder Reactions: Synthesis of Fused and Bridged Cycles. Angewandte Chemie International Edition, 56(28), 8163.
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